Many pathological circumstances are predominantly related to oxidative stress, arising from reactive oxygen species (ROS); due to this fact, the modulation of redox actions has been a key technique to revive regular tissue features. Present approaches contain establishing a positive mobile redox setting by means of the administration of therapeutic medicine and redox-active nanomaterials (RANs). Particularly, RANs not solely present a steady and dependable technique of therapeutic supply but in addition possess the capability to finely tune numerous interconnected elements, together with radicals, enzymes, proteins, transcription components, and metabolites. Right here, we focus on the roles that engineered RANs play in a spectrum of pathological circumstances, resembling most cancers, neurodegenerative illnesses, infections, and irritation. We visualize the twin features of RANs as each generator and scavenger of ROS, emphasizing their profound influence on numerous mobile features. The main focus of this assessment is solely on inorganic redox-active nanomaterials (inorganic RANs). Moreover, we deliberate on the challenges related to present RANs-based approaches and suggest potential analysis instructions for his or her future scientific translation.
