With distinctive benefits spanning glorious flexibility, wealthy bodily properties, sturdy electrostatic tunability, dangling-bond-free floor, and ease of integration, 2D layered supplies (2DLMs) have demonstrated super potential for photodetection. Nonetheless, so far, many of the analysis enthusiasm has been merely centered on growing novel prototype gadgets. Previously few years, researchers have additionally been dedicated to growing numerous downstream purposes primarily based on 2DLM photodetectors to contribute to selling them from basic analysis to sensible commercialization, and in depth accomplishments have been realized. Regardless of the exceptional developments, these fascinating analysis findings are comparatively scattered. Up to now, there may be nonetheless a scarcity of a scientific and profound summarization relating to this fast-evolving area. This isn’t helpful to researchers, particularly researchers simply coming into this analysis subject, who need to have a fast, well timed, and complete inspection of this fascinating area. To handle this situation, on this evaluation, the rising downstream purposes of 2DLM photodetectors in in depth fields, together with imaging, well being monitoring, goal monitoring, optoelectronic logic operation, ultraviolet monitoring, optical communications, computerized driving, and acoustic sign detection, have been systematically summarized, with the concentrate on the underlying working mechanisms. On the finish, the continuing challenges of this quickly progressing area are recognized, and the potential schemes to handle them are envisioned, which goal at navigating the long run exploration in addition to absolutely exerting the pivotal roles of 2DLMs in direction of the sensible optoelectronic trade.